Biochemical Engineer

PsiOxus Therapeutics Ltd is an Oxford based development stage biotechnology company developing novel therapeutics for the treatment of cancer, with a focus on immunotherapeutic approaches.  At PsiOxus we are advancing our internal early and clinical stage candidates and establishing strategic partnerships with immune-oncology leaders to bring our cancer gene therapy products to patients. 

The Role

As a part of our MSAT team, the jobholder will take a lead in defining and conducting the lab and plant work necessary to develop, optimise and scale up the associated upstream and downstream processing. The core function of the role is to lead and provide technical expertise on all aspects of process engineering.

The work will involve hands-on evaluation of process options and development/optimisation of processes in the laboratory and transfer of lab-scale processes to pilot plant and beyond. The role may entail supervision of junior scientists and will certainly require a close liaison with others within the team responsible for development and scale-up of the bioreactor process. 

For an outstanding performer there should be the opportunity to shape the role as the company develops.

The Person

• A proven engineer working in the establishment biological processes within cGMP environments. Ready to accept and be rewarded for establishing PsiOxus gene vector manufacturing as an exemplar to the industry.
• Engineer with qualification in appropriate technical area, probably (bio)chemical engineering or bioprocess engineering.
• Essential to have several years hands-on industrial experience in development of upstream processing (mammalian cell systems) for biologicals and transfer of these processes to plant scale.
• Essential to have hands-on experience with Upstream operations including SUB bioreactors as plant scale. 
• Experience in Downstream such as TFF, Chromatography and a range of filtration approaches is desirable.
• Experience in manufacturing in a GMP environment would be seen as an advantage
• Ambitious and keen to develop/continue a career in industrial biotechnology
• Self-starter who can quickly take the initiative in problem solving
• Professional and confident, with the ability to work effectively as part of a team
• Excellent written and verbal communication skills (English language)

In return we offer an attractive remuneration package including salary, pension, private healthcare and other benefits.  To apply please click on the Apply button to upload your CV and covering letter.


The closing date for applications is 30 November 2018, however applications will be evaluated in the order that they are received. You are therefore encouraged to apply as soon as possible.