Senior Analyst (Molecular Biology)

PsiOxus Therapeutics Ltd is an Oxford based biotechnology company developing novel therapeutics with a particular focus upon cancer.  The company has a diverse portfolio and currently has products in Phase I/II clinical development and an innovative pipeline of research stage and clinical trials candidates.


Reporting directly to the Analytical Manager this is an exciting new opportunity to take a prominent role in the PsiOxus GxP (Good Manufacturing/Clinical/Laboratory Practice) laboratories, to perform analysis of test material to support batch release, stability assessments, toxicology studies and samples from clinical trials, that adheres to relevant GxP quality standards.


Overall responsibilities will include, but are not limited to:

  • Routinely perform and document a range of molecular, cell based, biochemical, physicochemical, immunochemical (and other methods) assays, as required, for example:

  • Samples obtained during clinical trials
  • Batch release

  • Manufacturing samples generated at CMO

  • Stability samples

  • Generate analytical data, in accordance with GxP principles and PsiOxus policies and requirements.

  • Liaise with the analytical development group to support assay transfer, qualification, development, validation and routine analysis to support PsiOxus projects.

  • Author and technical review technical procedures, SOPs, protocols and reports, ensuring good quality guidelines are adhered to throughout.

  • Perform technical review of assay documentation, reports and other relevant GMP documentation.

  • Perform investigations OOS, Deviations, CAPAs, Change Control within the PsiOxus Quality System, as required.

  • Assist with audits and internal inspections.

  • Operate and maintain the office/laboratory facility and the systems within to both PsiOxus and GxP quality standards. For example:

    • Routine calibration and maintenance of equipment,

    • Timely completion of logbooks,

    • Ensuring equipment is correctly calibrated for use,

    • Assisting with equipment qualification and validation, where required.

  • Tracking and trending of data.

    • Timely completion of control charts.

    • Trending analysis of control chart data as per PsiOxus procedures.

    • Setting acceptance limits for assay methods.

  • Carry out sample receipt, storage, tracking and disposal to appropriate quality standards.

  • Provide technical guidance and training to other members of the department as required.

  • Maintain an up-to-date GxP training record.

  • Report all data, results, issues and potential delays to Line Managers.

  • Participate in PsiOxus self-inspections and regulatory inspections.

  • Report all data, results, issues and potential delays to Line Manager.

  • Travel, as may be reasonable, to meet project needs.


The successful applicant will have a minimum of three years practical laboratory experience in a biotechnology/pharmaceutical setting and an excellent knowledge of a range of biochemical / immunochemical techniques and molecular biology. In addition we are looking for the following attributes:

  • BSc or higher qualification in a life science discipline.

  • Good knowledge of GMP, GCP, GLP, ICH and other analytical regulatory guidelines.

  • Experience of technology transfer, assay development/validation and stability studies.

  • Proven ability to work and communicate effectively as part of a team and liaise with teams in other organisations.

  • Excellent attention to detail.

  • Good organisational skills.

  • Applicants must be self-motivated, work to tight deadlines and be capable of readily adapting to changing priorities in a fast-paced environment


The closing date for applications is 31 January 2018, however applications will be evaluated in the order that they are received. You are therefore encouraged to apply as soon as possible.