Process Development Scientist

PsiOxus Therapeutics Ltd is an award winning Oxford based development stage biotechnology company developing novel therapeutics for the treatment of cancer, with a focus on immunotherapeutic approaches.  We have a first- generation oncolytic virus in Phase I/II clinical development and are developing an innovative pipeline of clinical, pre-clinical and research candidates using our proprietary T-SIGn cancer gene therapy platform technology. 

The Company is at an exciting stage of development recently rated number 25 in The Sunday Times Hiscox Top Tech Track, and recognised in FierceBiotech’s 2017 Fierce 15 as one of only two European countries listed, and the only one in the UK. We have also been awarded at the Best Established Biotech at the 2017 OBN awards. Our headcount nearly doubled in 2017 and is set to grow substantially in 2018, offering significant future career opportunities for the right person.

We have an exciting opportunity for an Upstream Scientist to join us and be part of a Development team responsible for delivering improvements to the manufacturing process for our present clinical stage oncolytic vectors, as well as the next generation of viral cancer therapies.

Overall responsibilities will include, but are not limited to:

  • Develop and optimize upstream processes for producing adenovirus vectors.

  • Execute small scale and laboratory scale bioreactor cell culture activities for scale-up/scale-down of existing bioprocesses, together with supporting new product process development and scale-up activities. This requires working with miniature cell-cultivation systems, the scale-up to larger bioreactors and use of associated analytical support equipment.

  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation associated with the manufacture of new gene therapy vectors.

  • Performing high-throughput upstream studies and applying DoE methods to cell culture activities.

  • Liaising with other members of the Process MS&T Group and assisting with other development activities where necessary.

  • Routinely interact with the Manufacturing team to facilitate technology transfer of processes to the manufacturing facility and/or external CMOs as necessary.


The successful applicant will hold a degree (or equivalent) in a relevant scientific discipline and have some experience of working within biological research/biotechnology or pharmaceutical manufacturing in a GMP environment. Experience of working a similar role as a Scientist or Engineer with mammalian cell culture expertise and an understanding of bioprocess development and bioprocess unit operations is essential, together with the following attributes:

  • A sound understanding of basic cell culture principles and processes

  • Experience with downstream processing

  • Excellent written and verbal communication skills.

  • Proven ability to work and communicate effectively as part of a team and internal/external stakeholders.

  • Excellent attention to detail.

  • Good organisational skills.

  • Applicants must be self-motivated, work to tight deadlines and be capable of readily adapting to changing priorities in a fast-paced environment.

In return we offer an attractive remuneration package including salary, pension, private healthcare and other benefits. To apply please click on the Apply button to upload your CV and covering letter.


The closing date for applications is 27 July 2018, however applications will be evaluated in the order that they are received. You are therefore encouraged to apply as soon as possible.