Scientific Opportunities

PsiOxus Therapeutics Ltd is an Oxford based development stage biotechnology company developing novel therapeutics for the treatment of cancer, with a focus on immunotherapeutic approaches.  We have a first- generation oncolytic virus in Phase I/II clinical development and are developing an innovative pipeline of clinical, pre-clinical and research candidates using our proprietary T-SIGn cancer gene therapy platform technology. The company is looking to expand its scientific team to support research and development of new immuno-therapeutic viruses and further build on our platform capabilities. We have open positions at our Abingdon, Oxfordshire facility for laboratory-based scientists with an interest in pursuing a career in Biotech, who have the following expertise and experience:

 

1.  Molecular Cell Biology (REF: MCB-01)

This laboratory-based role will focus on the design, cloning and characterisation of novel virus candidates expressing immunotherapeutic transgenes. Applicants for this role must have at least a year of demonstrable practical experience of molecular biology techniques, including plasmid design, cloning, PCR, electrophoresis, bacterial amplification and DNA purification.  In addition to these core molecular biology skills, experience of RNA-based gene expression profiling technologies and strong experience of mammalian cell culture would also be advantageous.

 

2.  Cellular Immunology (REF: CI-01)

This laboratory-based role will focus on investigating the effects of novel virus candidates and their immunotherapeutic transgene products on human immune cell function.  The role will include the use of a wide range of immunology and other techniques to design, setup and implement investigations into virus activity and immune system function using blood and tissue samples from healthy donors or cancer patients, in vitro and ex vivo.  Candidates should have at least two years of demonstrable practical laboratory-based experience using in vitro cell-based immune response models. In particular, candidates should be able to demonstrate experience of T-cell assay systems (e.g. primary cell cultures, flow cytometry, ELISPOT) and ideally a range of supporting molecular and immunochemical assay techniques (e.g. ELISA, RT-qPCR and other gene expression approaches).

3.  Cell & Tissue Culture (REF: CATC-01)

This laboratory-based role will be primarily focused on applying a range of cell and tissue culture approaches to the generation, characterization and functional analysis of novel virus candidates and their immunotherapeutic transgene products. Candidates should have at least a year of demonstrable practical laboratory-based experience in primary cell and tissue culture techniques, together with experience of the design, set up, running and analysis of readout assays (e.g. ELISA, FACS, RNA profiling techniques and cell activity assays).

 

4.  Immunoassays (REF: IA-01)

This laboratory-based role will involve the development of a range of different assays, including immunochemical and cell-based assays, to support the non-clinical characterization of new virus candidates. Applicants for this role must have a minimum of two years demonstrable and relevant practical laboratory experience of immunoassay development and their application to research studies. This should include the selection and characterization of antibody reagents as well as techniques for screening panels of potential new antibodies suitable for specific immunoassay uses. One or more of the following additional experience and skills would also be desirable: biochemical assays; HPLC; bioassays or flow cytometry techniques.

 

5.  Clinical Assay Development (REF: CAD-01)

Two positions are available in a new group within the Research organization that will be responsible for developing new clinical assays for PK/PD and mechanistic evaluation of clinical trial samples from cancer patients. Some assays will be developed and then transferred to a GCP-compliant lab for testing, while more exploratory research analyses will be undertaken by this new Clinical Assay Development team.   While there may be some overlap in these two roles, one will be primarily focused on assays to measure relevant proteins in clinical biopsy or body fluid samples, in particular using different immunoassay approaches, while the other will focus on molecular analytical approaches to the detection of specific mRNA/DNA molecules. Applicants for these roles should have a minimum of 3-5 years demonstrable practical laboratory experience of relevant techniques (e.g. assay development, ELISA, multiplex analyte detection assays, qPCR, RT-qPCR, gene expression profiling etc). Experience with transferring assays to contract testing organizations, assay validation and qualification, design of experiments (DOE) and knowledge of regulatory guidelines and quality systems (e.g. ICH) would also be an advantage.

Successful candidates will have a life sciences degree and demonstrate excellent attention to detail, good organizational skills and an ability to meticulously and independently design and follow protocols to carry out and record experiments. They will be enthusiastic, diligent and team-oriented in their approach to work, together with having excellent communication skills, and preferably previous lab-based experience in industry.

Positions are available from 1 April 2018.  

The closing date is Friday 30 March 2018 however applications will be evaluated in the order that they are received, and you are therefore encouraged to apply as soon as possible.