Associate Scientist (Molecular Biology)

PsiOxus Therapeutics Ltd is an award winning Oxford based development stage biotechnology company developing novel therapeutics for the treatment of cancer, with a focus on immunotherapeutic approaches.  We have a first- generation oncolytic virus in Phase I/II clinical development and are developing an innovative pipeline of clinical, pre-clinical and research candidates using our proprietary T-SIGn cancer gene therapy platform technology.


The Company is at an exciting stage of development recently rated number 25 in The Sunday Times Hiscox Top Tech Track, and recognised in FierceBiotech’s 2017 Fierce 15 as one of only two European countries listed, and the only one in the UK. We have also been awarded at the Best Established Biotech at the 2017 OBN awards. Our headcount nearly doubled in 2017 and is set to grow substantially in 2018, offering significant future career opportunities for the right person.


The Role

This is an exciting new position working as part of the Hybrid Research Team supporting the development of novel oncolytic virus therapies for cancer. It will involve the generation of oncolytic viruses and their characterisation in in vitro assays using human primary cells and cancer cells and will include the design, setup and development of new experimental systems and assays for generating novel virus functions and anti-tumour activity. The role will also involve the development and application of in vitro and ex vivo techniques to provide new data that can help guide the development, mechanistic understanding and scientific decision making for the progression of different projects.

Key Activities will include, but are not limited to:

  • Assisting with the design, set up and development of molecular strategies to generate novel DNA virus strains.

  • Characterisation of the molecular composition of viruses using a variety of DNA and protein-based assays.

  • Perform cell-based assays and experiments using human primary cells, immune cells and cell lines to investigate virus activity.

  • Support Hybrid team’s in vitro studies, taking a lead role in a subset of these studies, including designing and carrying out in vitro studies, as well as providing a supportive role in other team studies.

  • Effectively and proactively communicate study designs/plans, data, interpretations/hypotheses as well as potential next steps in an appropriate and timely manner (both verbal and written) with Head of Future Projects and team members.

  • Establish, document and maintain appropriate operating processes and procedures to ensure that activities are carried out to appropriate standards of quality.

  • Ensure that the responsibilities progress according to plan and decisions are adhered to.

  • Provide input into study and experimental designs and ensure that all new ideas and technical know-how are appropriately identified and documented in a timely manner.

  • Provide input into the day to day operations of the Hybrid team facility.

  • Provide input and expertise to troubleshoot problems on any Hybrid project.

  • Identify and utilise sources of expertise - internal or external - where appropriate.

  • Adopt a strong team-oriented and openly communicative approach to all activities, while working independently and proactively where appropriate.


The Person


Technical Experience

We are looking for candidates that hold a minimum of a 2:1 degree or equivalent in Biochemistry, or a related subject and who have demonstrable experience in relevant academic or industrial laboratory research. Extensive molecular biology experience including complex DNA cloning strategies, gene- and protein expression analysis is essential together with the use of DNA analysis software to design and interpret genome modifications. Candidates must have experience in cell culture techniques, experience of designing, documenting and implementing in vitro assays; and can competently perform statistical analyses from results generated.


The ability to develop technical expertise where necessary across a wide range of in vitro and ex vivo techniques, including cell-based assays, microscopy, tissue culture techniques, immuno assays and -PCR platforms would be advantageous. Experience in virological techniques and in generating stable cell lines (using Lenti- or Retroviral transduction) is also highly desirable.


Personal Abilities and Traits

We are looking for a highly motivated scientist with an excellent team-based approach, but who can also work independently when necessary. Strong team and communication skills are essential together with flexibility in managing workloads across several activities. The successful candidate will be a highly effective communicator, both orally and in writing and will be able to demonstrate advanced problem-solving abilities.


In return we offer a competitive remuneration package including salary, pension, private healthcare and other attractive benefits. To apply please click on the Apply button to upload your CV and covering letter.


The closing date for applications is 29 June 2018, however applications will be evaluated in the order that they are received.  You are therefore encouraged to apply as soon as possible.