Project Director

PsiOxus Therapeutics Ltd is an award winning Oxford based development stage biotechnology company developing novel therapeutics for the treatment of cancer, with a focus on immunotherapeutic approaches.  We have a first- generation oncolytic virus in Phase I/II clinical development and are developing an innovative pipeline of clinical, pre-clinical and research candidates using our proprietary T-SIGn cancer gene therapy platform technology.

The Company is at an exciting stage of development recently rated number 25 in The Sunday Times Hiscox Top Tech Track, and recognised in FierceBiotech’s 2017 Fierce 15 as one of only two European countries listed, and the only one in the UK. We have also been awarded at the Best Established Biotech at the 2017 OBN awards. Our headcount nearly doubled in 2017 and is set to grow substantially in 2018, offering significant future career opportunities for the right people.

We are looking for an experienced Project Director to be accountable for leading the strategy and driving delivery of PsiOxus’ T-SIGN platform virus product(s) through the clinical development lifecycle, delivering key milestones and clinical results resulting in the commercialization and/or licensing of the product to a partner, according to corporate strategy.  These cross functional projects are of significant value (£ ‘Ms) and should be delivered on time, within budget and to the required quality standards within an acceptable risk profile against a backdrop of potentially competing pipeline priorities.

 

The Role: Overall Responsibilities

  • Being accountable for the creation, management and execution of the strategic development plan for a T-SIGN virus product(s). 

  • Being responsible for ensuring operational execution of the project(s) from candidate selection through key project milestones to product commercialization or out-licensing to a partner. The focus is directed towards on time delivery, on cost, risks managed & quality achieved.

  • Co-leading and directing cross-functional project teams comprising of multi-disciplines such as preclinical, regulatory, clinical, CMC/ manufacturing, quality, and translation medicine; internal and external members, (including, where necessary, consultants) to deliver the product lifecycle.  

  • Reviewing and challenging the target product profile and product development strategy against the ability to achieve project goals in line with corporate strategy and objectives.

  • Being accountable for the project budget(s) by developing and reporting against the project budgets and managing any scope changes, budget deviations and exceptions, in conjunction with the Finance team.

  • Representing, championing and communicating project progress status and the different functional areas when dealing with internal stakeholders such as the Executive team, Board members and external stakeholders, on behalf of PsiOxus Therapeutics, as and when required.

Key Activities

  • Ensuring the project is in control by: supervising (guiding, directing, questioning etc.) the project team to develop and track progress against a comprehensive project timeline; securing internal and external resources, monitoring and managing project risks and issues; and managing and communicating scope changes to the project.

  • Communicating, championing and influencing key stakeholders the project and its strategic direction in line with corporate needs within the company governance structure to ensure project visibility and timely decisions.

  • Acting as a Functional Lead on your project, where required, to liaise with external contacts to ensure definition, monitoring and delivery of project outcomes via the appropriate outsourcing strategies.

  • Chairing project team meetings - ensure the conduct of an efficient team meeting. Maintain action, decision, issue and risk logs etc, circulate agendas/minutes, perform risk management, contingency planning, formulate options and scenario modelling activities as required.

  • In concert with senior management team set objectives and expectations for the project.

  • Managing project issues - challenge, interrogate, escalate and ensure resolution of drug development issues across the project matrix, irrespective of the technical area in which they reside.

  • Ensuring learning, transfer and utilization of project management and drug development best practices across projects.

  • Ensuring all work undertaken on the project is covered by the appropriate legal framework including CDAs, MSA, and other such contracts and agreements and that the procurement process is adhered to for engaging new suppliers by working closely with the outsourcing team and other stakeholders.

  • Providing accurate and complete project information, including regular updates as required. Maintain project related systems, tools, dashboards, reporting cascades.

  • Contributing to design, development, improvement or redesign of project processes.

  • Acting as an additional resource within the business during busy times to provide support and assistance as required to make PsiOxus a success.

 

The Person

 

Technical Experience

In order to be consdered for this role candidates will ideally be postgraduate, PhD or MBA (or equivalent) and must have a minimum of 5 years cross functional project management/project leadership experience, reflecting a track record of project delivery generating significant value to an industrial organisation in the pharmaceutical or biotechnology field. Cross functional is defined as preclinical, regulatory, manufacturing, analytical development, clinical, supply chain, quality and translational medicine.  You should be able to demonstrate a comprehensive understanding of NCE, biologic and/or vaccine development process.

Specific expertise in the development of virology, vaccines, or oncology products is preferable.  Direct project management and/or clinical operations experience of early stage Phase I/II oncolytic virus and vaccine clinical trials would be advantageous.

You should be able to demonstrate the use of a project management tool kit in the areas of time, cost, quality and risk through the control of actions decisions and issue resolution; and have a good working knowledge of project management software including MS Project and Excel.

 

Personal Abilities and Traits

We are looking for enthusiastic, highly motivated and organised individuals with a flexible “can do” attitude and a strong focus and commitment to delivering.  You must have personal credibility - personal impact, knowledge, ability to understand and respond to project and business requirements, ability to challenge as appropriate without causing undue confrontation; and take action being able to represent different functional areas on behalf of PsiOxus when interacting with other external stakeholders. You should also have high personal integrity and professionalism with an open and straight forward style.

 

In return we offer a competitive remuneration package including salary, pension, private healthcare and other attractive benefits. To apply please click on the Apply button to upload your CV and covering letter.

 

The closing date is 31 August 2018, however applications will be evaluated in the order that they are received. You are therefore encouraged to apply as soon as possible.